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Approximately 5090% of the body's total B12 stores reside in the liver, making hepatic function important for maintaining adequate B12 status over time

Researchers are encouraged to identify whether the subclinical deficiency or deficiency itself of this vitamin is a risk factor for COVID-19 complications, and it is necessary to carry out intervention studies with vitamin B 12 supplementation in both the adjuvant treatment of mild, moderate, and severe COVID-19 and postCOVID-19, with a focus on minimizing symptoms related to the musclegutbrain axis

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This multi-modal approach makes it uniquely valuable for studying complex neurological conditions where multiple pathways are disrupted, and it crosses the blood-brain barrier via standard injectioneliminating the invasive delivery methods required by individual growth factors

B1 (Thiamine) Thiamine helps the body convert carbohydrates into energy and plays a key role in keeping the nervous system functioning properly

The foundational mechanism papers from the Washington State University lab that described how Dihexa works were retracted in April 2025 following a misconduct finding, with a third paper under an Expression of Concern since 2021