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This is because the water is able to form hydrogen bonds with the hydroxyl group in these molecules, and the increased stability in the system due to formation of these water-alcohol hydrogen bonds is more than enough to make up for the lost stability from undoing the alcohol-alcohol (and water-water) hydrogen bonds

Hutchens, J

A more targeted approach employs mitochondria-directed compounds such as Mito-VES, which incorporates a triphenylphosphonium (TPP) group to enable mitochondrial accumulation and rapid ROS generation [278]

Diabetes Care 1996;19:689-97

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Role of kidney injury molecule-1 expression, Wnt proteins (Beta-catenin), and endogenous irisin in a rat model of renal fibrosis: renoprotective effect of Metformin