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If theyre not destroyed quickly, degraded or malfunctioning cells can turn into things like cancer or cause inflammation

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Results from a five-year study

Notably, hypoxia also plays a critical role in epithelialmesenchymal transition (EMT) in cultured human proximal tubular epithelial (PTE) cells

Mice with genetic GH deficiency or humans with isolated GH deficiency are protected from aging phenotypes and show longevity (121)

10.1073/pnas.1411375111 [DOI] [PMC free article] [PubMed] [Google Scholar] Guillotin B, Rahni R, Passalacqua M, Mohammed MA, Xu X, Raju SK, Ramrez CO, Jackson D, Groen SC, Gillis J, et al