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Additionally, methionine (MET) treatment, which raises S-adenosyl methionine (SAM) levels, a cofactor for DNMT1, further enhances promoter methylation and gene silencing in schizophrenia-related pathways ( GAD1 ) gene promoter, encoding the enzyme responsible for GABA synthesis, exacerbates deficits in GABAergic transmission in schizophrenia patients (Ruzicka et al., 2015

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3.1 Influence on DNA transcription The oxidation of DNA and associated proteins caused by ROS activity has long been recognized to affect DNA transcription

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