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Deletion of p53 in cancer cells increases HIF-1 levels and enhances transcriptional activation of HIF-1-dependent VEGF and erythropoietin (EPO) in response to hypoxia, thus promoting EC proliferation, migration, and angiogenesis (63, 64)

4.2 Cellular cytotoxicity of FA-CMC-GNA NPs The cytotoxicity of FA-CMC-GNA NPs was assessed through the MTT assay using human normal liver cells (MRC-5)

Cancer Discov 2013;3:35062

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