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This is particularly relevant in tumor cells, as described below

CTLA-4 functions by outcompeting the co-stimulatory receptor CD28 for binding to ligands CD80 and CD86 on antigen-presenting cells, leading to an inhibitory signal that dampens T-cell activation (64). Essentially, the glycolytic lactate in GBM promotes Treg cell function and tumor evasion of the bodys immune system

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