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Description
For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative

Nat Cell Biol 11(11):13051314

Rat studies using collagen tubes containing GHK-Cu demonstrated increased nerve fiber regeneration, more Schwann cell proliferation, and restored skin innervation in healing wounds

Marquez, C

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Brousse, B., Magalon, K., Daian, F., Durbec, P
