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score 2 = between 5 and 15 cells of which less than 25% with an amoeboid morphology

During early development, the NP contains a relatively large amount of cells and a small amount of extracellular matrix (ECM), whereas the ECM/cell ratio is high in the mature NP [3, 4]

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This activation reduces the inhibitory binding between Caveolin-1 and eNOS, allowing greater eNOS activation and nitric oxide productionwith laboratory studies showing BPC-157 at 1 g/ml increases NO production 1.35-fold compared to controls

Nature 432: 332337 [DOI] [PMC free article] [PubMed] [Google Scholar] Birchmeier C., Birchmeier W., Gherardi E., Vande Woude G.F