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While definitive data is limited, some studies suggest pre-exercise dosing may increase the proportion of energy derived from fat during exercise, potentially enhancing training adaptations and fat loss

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Unfortunately, data on the efficacy of these techniques is lacking and many of these treatments have undesirable side effects

The structure-activity relationship (SAR) studies conducted by Chugai and subsequently by Eli Lilly explored modifications across the molecule's three principal domains: the tetrahydropyran ring system, the indazole heterocycle, and the substituted phenyl ring