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Consistent with the increase in survival signal, i.e., phosphorylation of p70S6K1 and MDM2, the apoptotic protein, cleaved caspase 3, significantly decreased in the HT29-P cells comparing to that in the HT29-L cells (Fig

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101 As Mertk-dependent efferocytosis requires the vitamin K-dependent PS-binding protein Gas6 for activation, these studies suggest that PS and PS receptors are drivers of both metastatic disease and immune escape

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