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Another recent study in mice found that both high and low FA levels impair hematopoiesis, resulting in DNA damage and compromised production of lymphocytes [149]

c , Immunoblot analysis of indicated proteins from HEK293T cells or HEK293T cells expressing control-tag or ER-tag

A second hydrogen peroxide molecule acts as a reducing agent to regenerate the resting state enzyme, producing a molecule of oxygen and water.36 Hydrogen peroxide though at low amounts tends to regulate some physiological processes such as signaling in cell proliferation, cell death, carbohydrate metabolism, mitochondrial function, and platelet activation and maintenance of normal thiol redox-balance,37 however, at high concentrations it has been reported to be very deleterious to cells.38 Hence, the ability of CAT to effectively limit H2O2 concentration in cells underlines its importance in the aforementioned physiological processes as well as being a first line antioxidant defense enzyme

Measurements of glucose consumption and lactate production L-lactate concentration was determined according to a previously published protocol 30

Chemical research in toxicology 22 , 11061115, doi: 10.1021/tx9000539 (2009)

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