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Functional and integrative medicine approaches rosacea as a systemic inflammatory condition involving: Gut dysfunction Immune dysregulation Histamine signaling Mast cell activation Neurovascular instability Skin barrier impairment Comprehensive treatment may include: Gut healing strategies Histamine support and DAO Microbiome restoration Anti-inflammatory nutrition Stress and cortisol regulation Advanced peptide therapies LL-37, KPV, and GLOW-based approaches may provide additional support for immune regulation, tissue recovery, and inflammatory balance when used within a broader clinical framework

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The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods