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We are talking about laboratory environments utilizing liquid chromatography-mass spectrometry, commonly deployed by anti-doping agencies like WADA (World Anti-Doping Agency) or USADA

[DOI] [PubMed] [Google Scholar] 88.National Center of Biotechnology Information IL17A interleukin 17A

Diabetes 57:14701481

When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways

Further compounding the problem is the fact that not all bartenders (or whoever is mixing the drink) use standard measurements of liquor
