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A 2023 randomized, phase 2 crossover trial by Hansen et al

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Immunomodulatory therapy Imiquimod, an immune modifier which acts on toll-like receptors, induces production of cytokines and chemokines from dendritic cells and monocytes

A family history of melanoma, the presence of multiple or atypical naevi and immunosuppression (for example following organ transplantation or long-term immunosuppressive therapy) also increase risk

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