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Small Mafs lack transcriptional activation domain and can form homodimers to repress ARE-mediated gene expression [150]

Examples include poly(N-isopropylacrylamide) (PNIPAM)-MSNs with thermo-responsive swelling for on-demand release of drugs and chitosan-MSNs with mucoadhesive character for oral delivery [73,74]

If symptoms persist, topical vaginal estrogen is the most effective pharmacologic treatment, directly restoring mucosal integrity with minimal systemic absorption

If pregnant, breastfeeding, or currently taking medication, consult a healthcare professional before use

When iron homeostasis in the body is out of balance, autophagy of ferritin (namely, ferritinophagy) mediated by nuclear receptor coactivator 4 (NCOA4) releases iron bounds to ferritin (Kruer, 2013

Oral tablets and capsules are the most common form