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456,457 The ATF6 pathway The third arm of the UPR is perhaps also the least complex, as only one proteinthe transcription factor ATF6takes on both the sensor and effector roles

First, academia should foster an environment conducive to the early stages of translation by determining clinical needs, assembling interdisciplinary teams, reforming academic promotion systems, collaborating with technology transfer offices and establishing regional translation centers

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2021;896 doi: 10.1016/j.ejphar.2021.173913

NAD(P)H oxidase associated superoxide production in human placenta from normotensive and pre-eclamptic women

A key limitation in the field is that only blood and faecal samples are available, and, as discussed above, the current biomarkers for intestinal permeability are not reliable enough to answer this question