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Similarly to the ALK-5, SMAD2/3/4 gene silencing did not alter gene expression of the major effector and downstream target of TGF-, PAI-1 (Supplementary Figs

In addition, MET amplification is one of the mechanisms of drug resistance of EGFR TKI (Kumar et al., 2020)

Nevertheless, CuP is prone to hydrolysis by proteases, resulting in treatment failure 34,37
, Reference Bonilla2024
And for some people who have HIV, or even for people who don't have HIV, the deposits of visceral fat can be problematic for their health
