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Chitosan- or PEI-coated nanoformulations leverage protonated amines to interact electrostatically with sialic acid-rich mucins, improving mucosal adhesion, residence time, and paracellular opening, thereby enhancing transport along the olfactory and trigeminal pathways (121, 122)

The biggest change is an outward movement of the cytoplasmic part of the 5th and 6th transmembrane helix (TM5 and TM6)

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S2CID 39710661

Under normal conditions, the small intestine contains a relatively low number of bacteria compared to the large intestine

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