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doi: 10.1097/AUD.0000000000000458

By inhibiting NNMT, 5-Amino-1MQ raises intracellular NAD+ and SAM levels, producing downstream effects on fat cell differentiation and metabolic rate

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this was associated with elevations of serum bile salts, suggesting impaired hepatic handling of bile salts.192 A more chronic exposure to Al3+ (3 months), which doubles the lipid-peroxidation levels, also reduced bile flow and the biliary output of bile salts.90 Compartmental analysis of the plasma decay of BSP revealed that both sinusoidal uptake and canalicular excretion are decreased.90 The latter phenomenon was associated with a decrease in Mrp2 protein expression

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