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Activation of sensory neuron TRPA1 channels downstream of reactive oxygen species produced by these CX3CR+ macrophages likely accounts for sensory symptoms associated with CIPN, at least in part (Old et al., 2014

Tanaka K, Sasayama T, Irino Y, Takata K, Nagashima H, Satoh N, Kyotani K, Mizowaki T, Imahori T, Ejima Y, Masui K, Gini B, Yang H, Hosoda K, Sasaki R, Mischel PS, Kohmura E

Paradoxically, in COPD patients, a higher body mass index is associated with improved survivalthe obesity paradoxindicating that weight management must be individualized rather than one-size-fits-all

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Kyriakou, V., Garagounis, I., Vourros, A., Vasileiou, E

Hyon, S