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However, excessive iron leads to the accumulation of reactive oxygen species within cells, disrupting intracellular redox balance, inducing mitophagy, membrane rupture, and lipid peroxidation, which can damage tissues and cells, ultimately resulting in ferroptosis

In parallel, therapeutic strategies should focus on targeting the shared mechanisms of neurotoxicity, such as oxidative stress and neuroinflammation, while considering drug-specific interventions

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doi: 10.1002/jor.22831

Absorption kinetics are broadly similar across the three permitted sites, though there is some evidence from GLP-1 pharmacokinetic literature that abdominal subcutaneous delivery produces slightly faster peak concentration compared to thigh or arm administration