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For example, ORG27569 binds to an allosteric site on CB1 receptors and enhances agonist binding but reduces agonist efficacy, thereby acting as a functional negative allosteric modulator (Price et al., 2005

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Annu Rev Biochem 52 :711760 Njlsson R, Norgren S (2005) Physiological and pathological aspects of GSH metabolism

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Synergy ideal but requires complementary mechanisms interacting favorably