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Furthermore, in tumor cells where IGF-1R and INSR are co-expressed, upregulated INSR can compensate for IGF-1R inhibition, thereby limiting sustained inhibition of downstream signaling and contributing to resistance to IGF-1R-targeted therapy [25, 26]

Concordantly, a 24-h acivicin treatment of tbb-6::GFP worms increased GFP fluorescence by approximately 6-fold (Fig
doi: 10.1002/pro.3691 127 ZhaoXZhuYHuJJiangLLiLJiaSet al

n = 5): Rats in this group were given a daily dosage of 25 mg/kg

None of the participants were pregnant or had kidney or liver disease

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