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In a hypoxic environment, the activity of PHD2 in osteocytes is reduced and HIF signalling is enhanced, improving the activity of the canonical Wnt signalling pathway through the HIF-SIRT1-SOST--catenin signalling axis, thereby promoting bone formation mediated by the activated Wnt/-catenin signalling pathway and inhibiting osteoclast bone resorption mediated by RANKL and OGP

10.2174/092986711796391624 15 ChengS.CastilloV.WeltyM.AlvaradoM.EliazI.TemmC

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Mitophagy induced by the BNIP3/NIX pathway may be related to the initiation of mitochondrial depolarization or the recruitment of autophagy components