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In drug-induced pyridoxine deficiency, such as in patients taking isoniazid, a higher replacement dose is often used, for example, 100 mg IV or IM daily for 3 weeks, to rapidly correct the deficiency, followed by a maintenance dose of around 30 mg daily

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Enhancing mitochondrial proteostasis reduces amyloid- proteotoxicity

SIRT3 lysine deacetylase inhibitors specifically target SIRT3 without affecting its structurally similar counterparts, SIRT1 and SIRT2 185,186

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Therefore, diseases of the pancreassuch as exocrine pancreatic insufficiency (EPI) and pancreatic cancer (as in Yukis case)often lead to B12 deficiency