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doi: 10.1038/s41590-021-00913-5 171 HuangY.MahleyR

Studied in models involving cellular repair signaling, tissue remodeling, and recovery-associated pathways

Preliminary findings indicate that TB-500 might enhance not only the viability, angiogenesis, and migration of HUVEC but could also elevate the expression of angiopoietin-2 (Ang2), TEK receptor tyrosine kinase 2 (tie2), vascular endothelial growth factor A (VEGFA), NOTCH1 intracellular domain (N1ICD), Notch receptor 3 (Notch3), NF-B, and phosphorylated (p)-p65 in these cells
The US Food and Drug Administration (FDA) will evaluate seven peptides in July to determine if they should be added to a list of substances that can be safely produced by compounding pharmacies

Don Catlin, worked to identify and expose these substances leading to one of the largest anti-doping scandals ever with the BALCO affair in 2002

Scale back on either frequency or concentration if you notice redness lasting more than a week
