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However, because IGF-1 signaling is involved in cellular proliferation pathways implicated in oncogenesis, existing or precancerous conditions are considered absolute contraindications

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Arch Gynecol Obstet 283(1):6165 Lazalde B, Grijalva-Flores J, Guerrero-Romero F (2012) Klippel-Feil syndrome in a boy exposed inadvertently to cyclophosphamide during pregnancy: a case report

Elemental mercury can be released from dental amalgam restorations [180] and can then be converted into inorganic mercury in the body which can accumulate in the brain [181]
10.1136/gutjnl-2024-331880 9 BaellJ
