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Similarly, under pathogenic infection, MEKK1-MKK4-MPK3/6 is identified to function upstream of NADPH oxidase trigger H 2 O 2 production, and this, in turn, leads to the further activation of MPK3 and MPK6 [118]

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It was shown that amiodarone has cytotoxic effects on different cell types in cell culture studies

[5]Huang F, Wang J.Preparation of polyolacrylate [P].China Patent, CN,200510013311.2,2005-11-9

Cell debris was removed by centrifugation at 4,400 g at 4 C for 30 min, and the clarified cell lysate was directly used for biocatalytic reactions