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The potent antioxidant activity of creatine could also protect mitochondrial DNA from ROS-mediated oxidative damage 543,544

Experiment groups (J2-5 + 293T): added both H 2 O 2 and cell-free supernatant of J2-5

A double-blind randomized controlled trial demonstrated that 24 weeks of taVNS intervention improved scores on multiple cognitive measures, including the Montreal Cognitive Assessment-Basic, Auditory Verbal Learning Test, and Boston Naming Test, with only mild and reversible adverse effects, confirming its clinical safety and efficacy (120)

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doi: 10.3390/ijms23010183

The use of MAO inhibitors and tricyclic antidepressants are no longer common practice in the treatment of depressive disorders