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Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a single bright light exposure in humans It makes sense, because the formation of melatonin requires a methyl group

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Vitamin C (ascorbic acid): High-dose vitamin C is acidic and can directly irritate the esophagus and stomach

Clinical experience in cell-based therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc