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[8] changed this paradigm

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Using this cream with other strong topical products such as prescription retinoids (e.g., tretinoin), chemical exfoliants (alpha- or beta-hydroxy acids), or benzoyl peroxide may increase irritation

Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis

But on average people notice differences in their skin after 2-4 weeks of consistent use

Propylene Glycol (PG): A reduced amount of propylene glycol (PG or PPG) is used as the delivery vehicle to shorten drying time and reduce irritation such as itchy scalp