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It was observed that in the treated group, the total motility and progressive motility of the spermatozoa were significantly higher than in the placebo group, demonstrating that an 80-day cycle with ALA after surgical repair is able to improve the total and progressive motility of the spermatozoa in subjects affected by varicocele

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The most significant changes in brain tissue included spongiform changes in neurons, especially within the hippocampus, nuclear deformity, and neurofibrillary degeneration, resembling the neurofibrillary tangles in AD.[16] These spongiform microscopic changes are usually indicative of excitotoxicity and not inflammatory changes alone