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doi: 10.3109/10717544.2014.907372, PMID: [DOI] [PubMed] [Google Scholar] 231.Gulati N, Nagaich U, Saraf S

These changes disrupted mitochondrial dynamics, leading to structural abnormalities, such as disorganized cristae, and excessive ROS production [187]

GSH synthesis in Mller glial cells is also considered to be important as GSH may be released from Mller glial cells and may be available to neurons to combat oxidative stress 7

Continuous lipid accumulation impairs mitochondrial function and elevates ROS production, 64 leading to lipid peroxidation, DNA damage, and protein denaturation, collectively initiating oxidative stress, inflammatory signaling, and hepatocellular injury