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(Ikram, Park, Ali, & Kim, 2020) studied the activity of trimethylxanthine in a PD model administrated with 6-OHDA
The up-regulation of EGF coupled with loss of cell cycle control (both p16 INK4A and p14 ARF ) was shown to induce higher-grade glioma formation in vivo

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SAS Institute, Cary, NC, USA)

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