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DNA methylation changes in genes involved in inflammation and depression in fibromyalgia: a pilot study

115 These findings may suggest protective effects on endothelial function from these nutraceuticals, and further research is needed to investigate their benefits in humans

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Many adults with CVS have sympathetic nervous system dysregulation.10,25,26 Studies have reported increases in sympathetic tone in patients with CVS, recorded through various tests of autonomic function, such as postural adjustment ratio, heart rate variability, tilt table test, and sudomotor tests.10,2729 The most frequent finding in these reports was an adrenergic anomaly, in addition to coexisting abnormalities of vagal cholinergic function

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In additional future studies, comparison of similar levels of ketosis induced endogenously or exogenously could help clarify to what extent ketones themselves might directly promote and/or alleviate different symptoms during keto-induction