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Likewise, determinations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) could not prove the hypothesis of reduced serotonergic transmission [70]

In comparison, the BERI study (NCT03213288), which measured plasma TMAO variability across six time points without dietary restrictions for trimethylamine precursors, reported that most participants exceeded 50% CV (44)