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Dihydrofolate reductase is a key enzyme in folate metabolism in vivo, responsible for the reduction of dihydrofolate to tetrahydrofolate, which is involved in the methyl shuttle required for the ab initio synthesis of thymidylate and certain amino acids

Does it actually work in humans

It is common for patients to be initially diagnosed with other conditions, such as depression, chronic fatigue syndrome and irritable bowel syndrome before receiving their pernicious anaemia diagnosis[20]

B12 helps your body use fats and carbohydrates for energy and make new protein, ultimately boosting energy

The gut mucosal response appears consistent across sex and hormonal status, making gut lining indications a strong match for female patients who are dealing with the GI consequences of hormonal fluctuation, antibiotic cycles, or inflammatory conditions

Until such trials are completed, the compound remains experimental