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While not a substitute for medical evaluation, this data can inform decisions about continued use

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Clinical Neuropharmacology, 16 (6), 540-549

Toxicology Findings Repeated-dose toxicity studies in rats, dogs, and mice for up to 6 weeks across doses from 6 mcg/kg to 20 mg/kg via various routes showed excellent tolerance

Thereby, PI3K and AKT transcription was downregulated 1.7- and 2-fold, respectively, whereas PGC-1 transcripts were increased 7-fold and AKT phosphorylation was reduced by 3550%