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With regards to dose, the benefits of carnitine are primarily demonstrated when serum carnitine levels increase

Within seconds, neuronal adenosine triphosphate (ATP) depletion triggers a glycolytic surge flooding cells with lactate, destabilizing pH, and paralyzing ion pumps, a biochemical crisis manifesting as cytotoxic edema and acute cognitive-motor dysfunction [16]

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A clear reduction in infarct size (measured by reductions in cardiac enzymes) has been observed in several AMI clinical trials [45,46], leading to improvements in myocardial viability and salvage

The majority of randomized controlled trials recruited only a small number of participants, were of relatively short duration (most lasted only 12 weeks), and used different forms and doses of garlic preparations

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