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These modifications include DNA methylation, post-translational histone modifications, chromatin rearrangement, and non-coding RNAs (ncRNAs) [118] (Figure 3)

[DOI] [PMC free article] [PubMed] [Google Scholar] 190.Neto IVS, Pinto AP, Muoz VR, de Cssia Marqueti R, Pauli JR, Ropelle ER, et al

The neuroprotective mechanisms may involve modulation of inflammatory responses within the central nervous system, promotion of neuronal survival, and enhancement of axonal regeneration and synaptic plasticity

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Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function