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Future patent activity will likely need to shift toward formulation engineering, targeted delivery to reproductive tissues, and the development of semi-synthetic derivatives aimed at overcoming luteolins pharmacokinetic limitations

Seminotti B, Grings M, Tucci P, Leipnitz G, Saso L (2021) Nuclear factor erythroid-2-related factor 2 signaling in the neuropathophysiology of inherited metabolic disorders

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The extraction solvent consisted of 80% methanol and 20% aqueous solution (pH 7.00) containing 10 mM ammonium formate (Sigma-Aldrich, 70221-25G-F) and 25 mM NEM (Thermo Scientific, 040526.06)