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Srinivas-Shankar U, Wu FC

The decline in microbiome-derived propionate production induced by fasting, likely contributed to the reduction in propionylcarnitine levels (Supplementary Fig

Interestingly, -ketoglutarate can be converted into glutamate, another metabolic intermediate and a neurotransmitter, by mitochondrial glutamate dehydrogenase in the GI tract

These findings suggest that cholesterol and FAs are negative factors for effector cells, for example, CD8 + T cells in the TME, whereas altering lipid metabolism can enhance their antitumor activity

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