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Changes in sphingolipids Levels of some long-chain hydroxylated and non-hydroxylated sphingolipid species differed between the MPTP and Ctrl groups, with notable differences observed in the GPi and GPe regions of the basal ganglia (Fig

We conclude that zebrafish-centric platforms furnish a robust, mechanism-driven, and scalable framework to accelerate the discovery, mechanistic elucidation, and rational preclinical development of safer, multi-target phytotherapeutics, thereby catalyzing the evolution of plant-based medicine from empirical discovery to precision anti-inflammatory therapy guided by a systems-level, mechanism-driven paradigm

Our drug-gene interaction analysis identified several promising therapeutic compounds, with erastin showing particularly strong binding affinity to SLC7A11

Nature 615:151157 Hao Y, Stuart T, Kowalski MH, Choudhary S, Hoffman P, Hartman A, Srivastava A, Molla G, Madad S, Fernandez-Granda C et al (2024) Dictionary learning for integrative, multimodal and scalable single-cell analysis

Such small increases in oxygen and pressure have shown biological (36)

It also influences your mood, memory and ability to focus