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The Exclusion criteria included symptoms of hemoptysis, known hypersensitivity to heparin, acetylcysteine, budesonide, and ipratropium bromide or related compounds, signs indicating imminent ICU admission, and presence of coagulation dysfunction (meeting any of the following criteria): coagulation function tests showed a hypocoagulable state

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Defined composition: Fixed amounts of each component to simplify comparative and combination studies

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