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Beside, c-MYC and other transcription factors, such as mTOR and HIF-1, can act synergistically to improve glycolysis and promote cancer proliferation (182, 183)
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Importantly, tumors with LOH have lower measurable GPx-1 enzyme activity and increased accumulation of 8-hydroxydeoxyguanosine, a pro-mutagenic DNA-oxidation product, suggesting that LOH results in oxidative stress in these tumors
Gaining a deeper insight into what role ferroptosis play in cutaneous diseases could help provide and optimize therapeutic options
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Therefore, no publication bias was considered
