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HNE inhibits inflammasome activation independently of NF-B signaling Activation of the inflammasome involves first the NF-B dependent stimulation of NLRP3 expression, and then NLRP3 oligomerization promoted by a cell danger signal, such as K + efflux or ATP (36)

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Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death