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Very high platelet levels over 400 may be linked to thrombocytosis, a coagulation disorder due to chronic inflammation

Restoring L-Glutamine reverses this process, directly stimulating the synthesis and correct membrane localization of both Claudin-1 and Occludin

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These fluid markers can be sampled longitudinally with minimal invasiveness, and combining them with TSPO-PET or other microglial/astrocytic imaging readouts yields a multimodal profile that better characterizes active neuroinflammatory states and may inform anti-inflammatory or disease-modifying treatment strategies (145)