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In fact, busulfan, through interaction with glutathione and sulfhydryl groups and disruption of balance between ROS and antioxidant, increases oxidative stress and causes extensive intracellular damages to proteins, nucleic acids, and lipid molecules

Liu XF, Hao JL, Xie T, Malik TH, Lu CB, Liu C, Shu C, Lu CW, Zhou DD (2017) Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress

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