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For exposure assessment human biomonitoring (HBM) based on the analysis of serum, plasma, whole blood, urine or breast milk samples is a powerful approach which has been extensively used

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It is commonly used in laboratory settings for the dilution and reconstitution of lyophilised materials where sterility and repeat-use stability are required

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The review also highlights the pitfalls of using indirect surrogatessuch as glutathione or cystathionine levelsto infer cysteine availability, which can lead to significant misinterpretation of metabolic states