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doi: 10.1038/nm.3955 [DOI] [PMC free article] [PubMed] [Google Scholar] 73

In one study, rats were fed a diet high in fat and ethanol to create an oxidized cellular environment, in which 4-hydroxynonenal (4-HNE) was used as a marker to identify modified proteins

Also, administration of melatonin exerts hepatoprotective effects in a rat model of CPB( cardiopulmonary bypass model) and SIRS(systemic inflammatory response syndrome) by reducing the ROS generation which is well demonstrated in biochemical and histo-pathological experiments [57,58]

James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al

Dosing recommendations contradict each other across sources